Vaccine, poliomyelitis


Generic Medicine Info
Indications and Dosage
Intramuscular, Subcutaneous
Active immunisation against poliomyelitis
Adult: As inactivated trivalent vaccine of polio virus types 1,2,3: Primary immunisation: 3 doses of 0.5 mL, given via IM or SC inj at least 8 weeks apart. Booster dose of 0.5 mL is given every 10 years for patient with increased risk of exposure.
Child: As inactivated trivalent vaccine of polio virus types 1,2,3: ≥6 weeks Primary immunisation: Same as adult dose. Booster dose of 0.5 mL is given at 4 years of age.
Contraindications
History of hypersensitivity to any component of the vaccine. Acute febrile illness.
Special Precautions
Patient with immunodeficiency, bleeding disorder/thrombocytopaenia. Postpone vaccination in patients with acute febrile illness. Children. Pregnancy and lactation.
Adverse Reactions
Significant: Inj site reactions (e.g. pain, redness, bruising, swelling, induration), syncope, bleeding, asthenia, fever, hypersensitivity reaction (e.g. anaphylaxis). In children, crying.
Blood and lymphatic system disorders: Lymphadenopathy.
Gastrointestinal disorders: Diarrhoea, nausea, vomiting.
General disorders and administration site conditions: Irritability.
Metabolism and nutrition disorders: Loss of appetite.
Musculoskeletal and connective tissue disorders: Myalgia.
Nervous system disorders: Headache, restlessness.
Skin and subcutaneous tissue disorders: Rash.
Patient Counseling Information
This drug may cause syncope, if affected, do not drive or operate machinery.
Monitoring Parameters
Monitor for hypersensitivity reactions 15 minutes after administration.
Drug Interactions
Increased risk of bleeding with anticoagulants. Decreased immune response with immunosuppressive therapies (e.g. high dose corticosteroids) and immunoglobulin.
Action
Description:
Mechanism of Action: Poliovirus vaccine inactivated (IPV) contains poliovirus type 1 (Mahoney strain), type 2 (MEF-1 strain), and type 3 (Saukett strain). It promotes active immunity by inducing production of antibodies against polio virus infection.
Synonyms: Salk vaccine.
Storage
Store between 2-8°C. Protect from light. Do not freeze.
Any unused portions should be disposed of in accordance with local requirements.
MIMS Class
Vaccines, Antisera & Immunologicals
ATC Classification
J07BF03 - poliomyelitis, trivalent, inactivated, whole virus ; Belongs to the class of poliomyelitis viral vaccines.
References
Anon. Poliovirus Vaccine (Inactivated). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 24/07/2018.

Anon. Poliovirus Vaccine Inactivated. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 24/07/2018.

Buckingham R (ed). Poliomyelitis Vaccines. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 24/07/2018.

IPOL, Poliovirus Vaccine Inactivated (Sanofi Pasteur Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 24/07/2018.

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